Post Office - Irene 205 W Main St Irene, SD 57037 Phone : (605) 263-3513 Business Category Post Offices Toll-Free           (800) ASK-USPS Fax           (605) 357-4906 United States Government--irene, Post Office 205 E Main St Irene, SD 57037 Phone : (605) 263-3513 Business Category Government Offices-Federal Post Offices Government Offices & Public Schools United States Postal Service , Phone : (605) 263-3513 United States Postal Service Business Category